Organs-on-chips are biotechnologically produced in vitro models that imitate the structure and function of human organs. By modeling the smallest functional unit of the organ, they enable the simulation of human physiology. The first organ-on-a-chip from the start-up AlveoliX AG simulates the microenvironment of the lung alveoli, in particular the air-blood barrier. The goal of AlveoliX is to change how drug research is conducted by providing new in vitro models that reproduce the in vivo environment in unprecedented ways. These in vitro models, i.e., organs-on-chips, make it possible to predict the human response to drugs better than conventional in vitro and in vivo models, and therefore significantly reduce the need for animal testing.
Two compact and intuitive devices – developed in collaboration
The AXExchanger pneumatically controls the valves of the cell culture chamber for a controlled fluid flow during medium exchange. The AXBreather pneumatically controls the deflection of the micromembrane, and therefore generates the cyclical breathing movement that can be set up for pressure curves of various shapes, repetitions, and frequencies. The devices are operated via touchscreen and allow the export of experimental data to a USB stick for documentation purposes. konplan designed and implemented the electronics and embedded software for both devices. The development team was made complete with process and mechanical experts from AlveoliX. konplan was the ideal partner for AlveoliX because they brought the missing know-how in the embedded software area and can respond to the needs of a start-up with agility.
First satisfied customers
The first customers in the clinical R&D industry are successfully using the devices and were able to perform initial research studies during the Covid-19 crisis of 2020 and 2021. konplan continues to support AlveoliX quickly and efficiently with the implementation of new software features and as a reliable and strong partner who will help AlveoliX exceed customer requirements and advance further in the market.